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pentobarbital decreases levels of ponatinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Prevent Except the coadministration outweighs the possible risk of ponatinib underexposure; observe for indications of diminished efficacy.pentobarbital will reduce the level or impact of ombitasvir/paritaprevi